Endocrine Abstracts

Adiponectin, the most abundant peptide hormone secreted from adipose tissue, has been negatively correlated with obesity and can induce varying responses on bone. There are significant discrepancies in the published data, showing increased, decreased or no effects on bone turnover.We investigated the effects of adiponectin on the human osteosarcoma cell line Saos-2. After culture with varying concentrations of adiponectin (10–100 nM), supernatants w...

TESTOSTERONE-REPLACEMENT STIMULATED HYPERPROLACTINAEMIAR Sodi, R Fikri, M Diver, L Ranganath & J Vora*.Departments of Clinical Chemistry and Endocrinology*Royal Liverpool and Broadgreen University Hospital,Liverpool, UK. L7 8XP.Around half of all men with macroprolactinomas have hypogonadism and may require exogenous testosterone replacement. However, testoste...

Introduction: There is increasing evidence suggesting that adiponectin plays a role in the regulation of bone metabolism. We have studied the changes in the circulating concentration of adiponectin in lean and obese post-menopausal women with and without osteoporosis and its association with a marker of bone formation – type 1 procollagen amino-terminal pro-peptide (P1NP) and a marker of bone resorption – type 1 collagen C-telopeptide (βCTX).<p class="abstex...